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The different types of Charco-Marie-Tooth disease symptoms and what they are.
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Different types of Charco-Marie-Tooth disease symptoms
This is info about the hereditary Charcot-Marie-Tooth disease symptoms
I have Charco-Marie-Tooth disease symptom Type 1
There are different types of Charco-Marie-Tooth disease symptoms and there are 4 different types of Charco-Marie-Tooth disease symptoms written. On this page explains what each type of CMT is and what it does.
Scroll down the page to read about each type
Charco-Marie-Tooth disease symptom Type 1
Charco-Marie-Tooth (CMT) Type 1 is a hereditary neurological disorder that affects the peripheral nerves. It's characterized by progressive muscle weakness and wasting, particularly in the lower limbs.
CMT type 1 is associated with demyelination, which is the loss of the protective covering (myelin sheath) around nerves. The demyelination in CMT type 1 leads to impaired nerve signal transmission and results in weakness, sensory abnormalities and foot deformities.
There are different subtypes of CMT, and type 1 is further divided into subtypes based on genetic factors. It is primarily caused by mutations in genes related to the production of myelin or structural components of peripheral nerves.
Charco-Marie-Tooth disease symptom Type 2
Charco-Marie-Tooth disease (CMT) Type 2 is a subtype of CMT, which is a group of inherited peripheral neuropathies affecting the peripheral nerves.
Symptoms of CMT Type 2 typically include muscle weakness and atrophy, primarily in the lower limbs.
Patients may experience difficulty walking, frequent tripping and foot deformities. Unlike CMT Type 1, which involves demyelination of nerves, Type 2 is associated with axonal damage.
Charco-Marie-Tooth disease symptom Type 3
Charco-Marie-Tooth disease symptom (CMT) Type 3, also known as distal hereditary motor neuropathy (dhmn) or Charcot-Marie-Tooth disease type 2 with pyramidal features (CMT2P), is characterized by symptoms that primarily affect the peripheral nerves, leading to muscle weakness and atrophy, particularly in the lower limbs. Individuals with CMT Type 3 may also experience difficulties with balance and coordination.
Additionally, some people with CMT Type 3 may exhibit pyramidal features, which involve the upper motor neurons. This can result in spasticity, increased muscle tone, and hyperactive reflexes.
The combination of peripheral nerve and upper motor neuron involvement distinguishes CMT Type 3 from other forms of Charcot-Marie-Tooth disease.
Charco-Marie-Tooth disease type 4
Charco-Marie-Tooth disease type 4 (CMT 4) is a subtype of Charcot-Marie-Tooth (CMT) disease, which is a group of inherited neurological disorders affecting the peripheral nerves.
CMT4 specificallyis a subset of autosomal recessive forms of CMT, meaning that both parents must carry a mutated gene for a child to inherit the disorder.
CMT 4 is characterized by progressive muscle weakness and wasting, particularly in the extremities. Symptoms often appear in childhood or adolescence. The disease is caused by mutations in various genes, affecting proteins essential for the normal function of peripheral nerves.
It's important to note that there are multiple subtypes of CMT (1-4), each associated with specific genetic mutations. CMT4 encompasses a range of genetic variations leading to similar clinical features.
As research progresses, more specific genetic subtypes and targeted treatments may be identified.
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